306. The Alzheimer's Drug With a 25% Brain Bleed Risk - Dr. David Perlmutter
You might think Alzheimer's starts in your 70s. Dr. David Perlmutter explains why it begins decades earlier, and how the p-tau 217 blood test flags risk long before symptoms appear. Gary Brecka and Dr. Perlmutter break down microglia, insulin resistance, pre-diabetes, APOE4, homocysteine, vitamin D, creatine and sleep, plus what the POINTER study showed about cognitive decline in metabolically compromised adults.
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Timestamps
00:00 - Intro of the Show
01:33 - Grain Brain and ultra-processed carbohydrates
03:26 - Pre-diabetes decades before any symptoms
08:03 - Type 3 diabetes and insulin in the brain
11:48 - The fasting insulin level to target
14:08 - Immunometabolism and your microglial cells
16:12 - APOE4 as predisposition, not destiny
19:25 - Inflammation from the gut, mouth and air
25:50 - Aerobic vs resistance training for the brain
30:04 - Sarcopenia, myokines and BDNF
34:44 - Mitochondria and the TSPO brain scan
40:11 - The Tanzi, Ornish and POINTER trials
46:31 - Beta-amyloid drugs and the Cochrane data
55:00 - Sleep, the glymphatic system and insulin
58:25 - Creatine dosing and the creatinine confusion
1:03:52 - Vitamin D, VDR polymorphisms and tau
1:09:35 - Fish oil, DHA and the omega-3 study
1:12:48 - Homocysteine, B complex and MTHFR
1:18:43 - Red light, RNS60 and mitochondrial transplant
1:27:11 - Isolation, cortisol and oxytocin
1:32:58 - What it means to be an ultimate human
Disclaimer: This podcast is for informational purposes only and does not provide medical advice. It is not intended for diagnosing or treating any health condition. Always consult a licensed healthcare professional before making health or wellness decisions.
Gary Brecka is the owner of Ultimate Human, LLC which operates The Ultimate Human podcast and promotes certain third-party products used by Gary Brecka in his personal health and wellness protocols and daily life and for which Ultimate Human LLC and / or Gary Brecka directly or indirectly holds an economic interest or receives compensation. Accordingly, statements made by Gary Brecka and others (including on The Ultimate Human podcast) may be considered promotional in nature.
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